Effect of smoking on Brain-Derived Neurotrophic Factor (BDNF) blood levels: A systematic review and meta-analysis.

BACKGROUND: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that plays a crucial role in neuronal survival and plasticity. Previous studies have suggested that smoking may influence BDNF levels, but the findings have been inconsistent. METHODS: A comprehensive search of electronic databases was conducted to identify relevant studies. Inclusion criteria were applied to select studies that investigated the relationship between smoking and blood levels of BDNF. A random-effects model was used to estimate the overall effect size. RESULTS: A total of 23 studies were included. The meta-analysis revealed a significant association between smoking and increased blood levels of BDNF (standardized mean difference [SMD] = -0.38, 95 % confidence interval [CI] 0.15 to 0.62, p = 0.002). Subgroup analyses based on BDNF source showed a significant increase in plasma-derived BDNF levels (SMD = 1.02, 95 % CI 0.50 to 1.53, p = 0.0001), while no significant difference was observed in serum-derived BDNF levels (SMD = 0.02, 95 % CI -0.19 to 0.22, p = 0.87). The pooled analysis revealed a non-significant difference in blood levels of BDNF between former smokers and non-smokers (random-effects model, SMD = 0.21, 95 % CI -0.04 to 0.46, p = 0.1). CONCLUSION: Smokers exhibited significantly higher plasma levels of BDNF compared to non-smokers. Further research is needed to elucidate the underlying mechanisms and explore the potential therapeutic implications of targeting BDNF in smoking.

First Successful Human Coronary Artery Bypass Surgery Postoperative Heart Transplant: A Case Report.

Heart transplant is now the treatment of choice for patients with advanced heart failure who are refractory to medical treatment. With a small number of candidates who meet the traditional criteria of a heart donor, we aimed to alleviate this shortage. In this article, we report a 43-year-old woman with a highly urgent heart requirement, according to acute decompensated heart failure, who received a heart with coronary artery grafts from a 50-year-old woman with the diagnosis of 3-vessel disease. Our review of her 1-year follow-up demonstrated the absence of any cardiac or other problems and survival of the patient. There have been no reports in the relevant literature of transplanting marginal hearts from donors who have previously undergone coronary artery bypass graft before transplant. According to our findings, transplant of a marginal heart with coronary artery grafts can be successful; additional studies with larger samples are warranted to further investigate the results of transplanting marginal hearts from donors who have previously undergone coronary artery bypass graft procedures.